Investigational Amylin-Based Weight Management Trial
Obesity is a chronic medical condition that can affect overall health and increase the risk of developing conditions such as high blood pressure, high cholesterol, sleep apnoea, cardiovascular disease, and fatty liver disease.
Study overview
Obesity is a chronic medical condition that can affect overall health and increase the risk of developing conditions such as high blood pressure, high cholesterol, sleep apnoea, cardiovascular disease, and fatty liver disease.
Researchers are studying an investigational medicine designed to evaluate whether it, when combined with healthy eating and regular physical activity, may help support long-term weight management. This study will examine the investigational medicine's safety, tolerability, and its effects on health and wellbeing over time.
Am I eligible?
You may be eligible if you:
- Are aged 18 years or older
- Have a BMI of 30 kg/m² or higher, OR have a BMI of 27 kg/m² or higher and at least one weight-related health condition, such as high blood pressure, high cholesterol, sleep apnoea, cardiovascular disease or fatty liver disease (MASLD)
- Have previously tried to lose weight through dietary measures without long-term success
- Are not currently taking a GLP-1
- Are willing and able to attend scheduled study visits and assessments
- Are willing and able to self-administer a weekly injection
Indicative only. Eligibility is confirmed by our team at screening.
What taking part involves
If eligible, participation in the main study will last approximately 79 weeks, including screening, treatment, and follow-up. Participants who complete the main study may also be eligible to continue into an Open-Label Extension (OLE), where all participants receive the investigational medicine, subject to meeting the study requirements.
Participants will be randomly assigned to receive either the investigational medicine or placebo. Neither participants nor the study team will know which treatment has been assigned during the study.
The study treatment is self-administered once weekly as an injection under the skin using an autoinjector device.
Researchers will closely monitor participants' health, wellbeing, and safety throughout the study. Study procedures may include physical examinations, blood tests, ECGs, body measurements, questionnaires, and other health assessments.
Clinic visits will take place during business hours of 9am–5pm, Monday–Friday. Visit lengths may vary depending on the assessments required at each visit.
- 1
Enquiry & phone call
We call to explain the study and answer your questions.
- 2
Screening visit
Meet the team and have health checks to confirm eligibility.
- 3
Study visits
Regular visits with expert care and health monitoring.
- 4
Final visit & follow-up
A wrap-up check and a thank-you for helping research.
Still have questions?
Our team is happy to talk it through. Call 1300 742 326.
Frequently asked questions
A clinical trial is a research study involving volunteers that helps researchers evaluate new treatments, medications, medical devices or approaches to healthcare. Clinical trials help determine whether these interventions are safe, effective and appropriate for wider use.
Clinical trials help advance healthcare by showing how treatments work, identifying possible side effects and exploring new ways to prevent, diagnose and manage medical conditions. By taking part, volunteers contribute to knowledge that may benefit people in the future.
Each trial has its own eligibility criteria, which may relate to your age, medical history, health conditions or current medications. Some studies are for people with a specific condition, while others involve healthy volunteers. Our research team can help you understand whether a study may be suitable.
Participant safety and wellbeing are central to clinical research. In Australia, trials must meet strict ethical and regulatory requirements and are reviewed by a Human Research Ethics Committee (HREC). Participants are monitored throughout the study.
All clinical trials involve some uncertainty and level of risk. Before you decide, the research team will explain the known and potential risks, possible benefits and available alternatives.