Non-GLP-1 Treatment for Obesity with a Weight-Related Health Condition
This clinical research study is evaluating an investigational long-acting amylin analogue treatment (administered as a once-weekly, every other week or a once a month self-administered injection) for weight management.
Study overview
This clinical research study is evaluating an investigational long-acting amylin analogue treatment (administered as a once-weekly, every other week or a once a month self-administered injection) for weight management. The investigational treatment is a man-made protein that works like a naturally occurring hormone in your body. This hormone tells your brain you feel full after eating. Researchers are investigating whether different dose levels of this investigational treatment may support weight management in adults living with obesity, or who are overweight and have a weight-related health condition, when combined with diet and physical activity guidance.
Am I eligible?
You may be eligible if you:
- Are aged 18 to 75 years
- Have obesity (BMI ≥30), OR are overweight (BMI ≥27) and have a weight-related health condition such as high blood pressure, high cholesterol, prediabetes, obstructive sleep apnoea, or fatty liver disease (also known as non-alcoholic fatty liver disease, MASLD/MASH)
- Have previously tried to lose weight through dietary measures
- Have not had a significant change in body weight (greater than 5%) in the past 3 months
- Have not been diagnosed with diabetes
- Are not currently using prescription weight-loss medications
- Are willing and able to attend scheduled study visits and complete study assessments
Indicative only. Eligibility is confirmed by our team at screening.
What taking part involves
If eligible, participation includes a screening period, a treatment period, and a follow-up period.
Participants will be randomly assigned to receive investigational treatment or placebo. Neither participants nor the study team will know which treatment has been assigned during the study.
The study treatment is self-administered as an injection under the skin (subcutaneous injection).
Participation includes approximately 52 weeks of treatment, followed by a 60-day follow-up period, with around 17 clinic visits. Researchers will closely monitor participants’ health, wellbeing, and safety throughout the study.
Study procedures may include physical examinations, blood tests, fasting assessments, body measurements, questionnaires, medical history reviews, and other health assessments.
- 1
Enquiry & phone call
We call to explain the study and answer your questions.
- 2
Screening visit
Meet the team and have health checks to confirm eligibility.
- 3
Study visits
Regular visits with expert care and health monitoring.
- 4
Final visit & follow-up
A wrap-up check and a thank-you for helping research.
Still have questions?
Our team is happy to talk it through. Call 1300 742 326.
Frequently asked questions
A clinical trial is a research study involving volunteers that helps researchers evaluate new treatments, medications, medical devices or approaches to healthcare. Clinical trials help determine whether these interventions are safe, effective and appropriate for wider use.
Clinical trials help advance healthcare by showing how treatments work, identifying possible side effects and exploring new ways to prevent, diagnose and manage medical conditions. By taking part, volunteers contribute to knowledge that may benefit people in the future.
Each trial has its own eligibility criteria, which may relate to your age, medical history, health conditions or current medications. Some studies are for people with a specific condition, while others involve healthy volunteers. Our research team can help you understand whether a study may be suitable.
Participant safety and wellbeing are central to clinical research. In Australia, trials must meet strict ethical and regulatory requirements and are reviewed by a Human Research Ethics Committee (HREC). Participants are monitored throughout the study.
All clinical trials involve some uncertainty and level of risk. Before you decide, the research team will explain the known and potential risks, possible benefits and available alternatives.