Acne Vaccine Clinical Trial
Acne is one of the most common skin conditions worldwide. This study is designed to evaluate the safety, effectiveness, and immune response of an investigational mRNA-based acne vaccine in adults aged 18 to 45 with moderate to severe acne.
Study overview
Acne is one of the most common skin conditions worldwide. This study is designed to evaluate the safety, effectiveness, and immune response of an investigational mRNA-based acne vaccine in adults aged 18 to 45 with moderate to severe acne.
The investigational vaccine targets specific proteins in C. acnes that contribute to inflammation and acne development.
Am I eligible?
- Aged 18–45
- Moderate to severe facial acne
- Willing to undergo a washout of acne treatments
- No prior use of oral isotretinoin (Accutane)
- Using contraception or post-menopausal (if female)
- No other facial skin conditions affecting assessments
What taking part involves
If eligible, participants will be on study for 8 months, with optional long-term follow-up up to 3 years. There will be 13 clinic visits, including physical exams, vital signs, ECGs, blood tests, pregnancy tests, and vaccinations.
Participants will receive 2 vaccinations using different dose combinations of the investigational vaccine or placebo. This is a blinded study, meaning participants will not know which group they are assigned to.
- 1
Enquiry & phone call
We call to explain the study and answer your questions.
- 2
Screening visit
Meet the team and have health checks to confirm eligibility.
- 3
Study visits
Regular visits with expert care and health monitoring.
- 4
Final visit & follow-up
A wrap-up check and a thank-you for helping research.
Still have questions?
Our team is happy to talk it through. Call 1300 742 326.
Frequently asked questions
A clinical trial is a research study involving volunteers that helps researchers evaluate new treatments, medications, medical devices or approaches to healthcare. Clinical trials help determine whether these interventions are safe, effective and appropriate for wider use.
Clinical trials help advance healthcare by showing how treatments work, identifying possible side effects and exploring new ways to prevent, diagnose and manage medical conditions. By taking part, volunteers contribute to knowledge that may benefit people in the future.
Each trial has its own eligibility criteria, which may relate to your age, medical history, health conditions or current medications. Some studies are for people with a specific condition, while others involve healthy volunteers. Our research team can help you understand whether a study may be suitable.
Participant safety and wellbeing are central to clinical research. In Australia, trials must meet strict ethical and regulatory requirements and are reviewed by a Human Research Ethics Committee (HREC). Participants are monitored throughout the study.
All clinical trials involve some uncertainty and level of risk. Before you decide, the research team will explain the known and potential risks, possible benefits and available alternatives.